Seminal vesicle amyloid: The first example of exocrine cell origin of an amyloid fibril precursor
Article first published online: 16 JUN 2005
Copyright © 1992 John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 167, Issue 3, pages 297–303, July 1992
How to Cite
Cornwell, G. G., Westermark, G. T., Pitkanen, P. and Westermark, P. (1992), Seminal vesicle amyloid: The first example of exocrine cell origin of an amyloid fibril precursor. J. Pathol., 167: 297–303. doi: 10.1002/path.1711670307
- Issue published online: 16 JUN 2005
- Article first published online: 16 JUN 2005
- Manuscript Accepted: 7 JAN 1992
- Manuscript Received: 14 OCT 1991
- Swedish Medical Research Council. Grant Number: (Project No. 5941)
- W. P. Cornwell Amyloid Research Fund
- seminal vesicles;
- exocrine cells
Amyloid fibrils have been extracted from seminal vesicles, and a dominant 14 kD amyloid fibril protein has been identified. An antiserum to this protein reacted both with amyloid and with epithelial cells in some normal seminal vesicles. These reactions were blocked with seminal vesicle secretion and seminal vesicle amyloid fibril protein, but not by degraded amyloid fibrils or fibril protein from other types of amyloid. It is concluded that seminal vesicle amyloid is derived from secretory proteins of the seminal vesicles. As such, it is the first amyloid described which appears to be the product of an exocrine secretory cell.