Three-dimensional reconstruction of human embryonic notochords: Clue to the pathogenesis of chordoma
Article first published online: 15 JUN 2005
Copyright © 1993 John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 171, Issue 1, pages 59–62, September 1993
How to Cite
Salisbury, J. R., Deverell, M. H., Cookson, M. J. and Whimster, W. F. (1993), Three-dimensional reconstruction of human embryonic notochords: Clue to the pathogenesis of chordoma. J. Pathol., 171: 59–62. doi: 10.1002/path.1711710112
- Issue published online: 15 JUN 2005
- Article first published online: 15 JUN 2005
- Manuscript Accepted: 27 APR 1993
- Manuscript Received: 12 MAR 1993
- Bone neoplasms;
- computer-assisted image processing;
Three-dimensional reconstruction experiments performed on serial sections of human embryos showed that the anatomy of the caudal and rostral ends of the notochord was complex. Forking of the ends, with separate fragments of chordal tissue, was demonstrated and these provide a way by which notochordal cell rests could be left behind in the basicranial and sacral regions when the notochord involutes elsewhere. Assuming the histogenesis of chordomas from notochordal cell rests, this would furnish an explanation for the observed skeletal distribution of chordomas.