These authors contributed equally to this work
Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas
Article first published online: 21 JUN 2007
Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 213, Issue 1, pages 99–105, September 2007
How to Cite
Leich, E., Haralambieva, E., Zettl, A., Chott, A., Rüdiger, T., Höller, S., Müller-Hermelink, H.-K., Ott, G. and Rosenwald, A. (2007), Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas. J. Pathol., 213: 99–105. doi: 10.1002/path.2196
No conflicts of interest were declared.
- Issue published online: 9 AUG 2007
- Article first published online: 21 JUN 2007
- Manuscript Accepted: 24 APR 2007
- Manuscript Revised: 24 MAR 2007
- Manuscript Received: 30 JAN 2007
- mature T-cell lymphoma;
- isochromosome 7
The pathogenesis of mature T-cell non-Hodgkin lymphomas (T-NHLs) is poorly understood. Analogous to B-cell lymphomas, in which the immunoglobulin (IgH) receptor loci are frequently targeted by chromosomal translocations, the T-cell receptor (TCR) gene loci are affected by translocations in a subset of precursor T-cell malignancies. In a large-scale analysis of 245 paraffin-embedded mature T-NHLs, arranged in a tissue microarray format and using improved FISH assays for the detection of breakpoints in the TCRα/δ, TCRβ, and TCRγ loci, we provide evidence that mature T-NHLs other than T-cell prolymphocytic leukaemia (T-PLL) also occasionally show a chromosomal rearrangement that involves the TCRα/δ locus. In particular, one peripheral T-cell lymphoma (not otherwise specified, NOS) with the morphological variant of Lennert lymphoma displayed a chromosomal translocation t(14;19) involving the TCRα/δ and the BCL3 loci. A second case, an angio-immunoblastic T-cell lymphoma (AILT), carried an inv(14)(q11q32) affecting the TCRα/δ and IgH loci. FISH signal constellations as well as concomitant comparative genomic hybridization (CGH) data were also suggestive of the occurrence of an isochromosome 7, previously described to be pathognomonic for hepatosplenic T-cell lymphomas, in rare cases of enteropathy-type T-cell lymphoma. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.