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jws-path.2218.fig1.tif14125KProton pump inhibitors had no effect on STAT3 and ERK signaling. Since the majority of patients who provided biopsies for this study take proton pump inhibitors (PPIs), we investigated whether these medications altered STAT3 and ERK1/2 activation, and thus potentially modified disease activity. PPIs had no effect on STAT3 in the normal (p=0.67) or H. pylori+ gastritic (p=0.49) antrum. Similarly there were no effects of PPIs upon the degree of ERK1/2 activation in the normal (p=0.89) or H. pylori+ gastritic (p=0.08) antrum.

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