No conflicts of interest were declared.
The role of inflammatory and parenchymal cells in acute pancreatitis†
Article first published online: 24 SEP 2007
Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 213, Issue 3, pages 239–248, November 2007
How to Cite
Vonlaufen, A., Apte, M., Imhof, B. and Frossard, J. (2007), The role of inflammatory and parenchymal cells in acute pancreatitis. J. Pathol., 213: 239–248. doi: 10.1002/path.2231
- Issue published online: 16 OCT 2007
- Article first published online: 24 SEP 2007
- Manuscript Accepted: 27 JUL 2007
- Manuscript Revised: 11 JUL 2007
- Manuscript Received: 16 APR 2007
- acute pancreatitis;
- parenchymal cells;
The infiltration of inflammatory cells into the pancreas is an early and central event in acute pancreatitis that promotes local injury and systemic complications of the disease. Recent research has yielded the important finding that resident cells of the pancreas (particularly acinar and pancreatic stellate cells) play a dynamic role in leukocyte attraction via secretion of chemokines and cytokines and expression of adhesion molecules. Significant progress has been made in recent years in our understanding of the role of leukocyte movement (adhesion to the blood vessel wall, transmigration through the blood vessel wall and infiltration into the parenchyma) in the pathophysiology of acute pancreatitis. This review discusses recent studies and describes the current state of knowledge in the field. It is clear that detailed elucidation of the numerous processes in the inflammatory cascade is an essential step towards the development of improved therapeutic strategies in acute pancreatitis. Studies to date suggest that combination therapy targeting different steps of the inflammatory cascade may be the treatment of choice for this disease. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.