Both authors contributed equally to this work and are listed in alphabetic order.
Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy†
Article first published online: 11 DEC 2007
Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 214, Issue 4, pages 415–424, March 2008
How to Cite
Thal, D., Xavier, C.-P., Rosentreter, A., Linder, S., Friedrichs, B., Waha, A., Pietsch, T., Stumpf, M., Noegel, A. and Clemen, C. (2008), Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy. J. Pathol., 214: 415–424. doi: 10.1002/path.2308
No conflicts of interest were declared.
- Issue published online: 8 FEB 2008
- Article first published online: 11 DEC 2007
- Accepted manuscript online: 11 DEC 2007 12:00AM EST
- Manuscript Accepted: 22 NOV 2007
- Manuscript Revised: 18 NOV 2007
- Manuscript Received: 14 SEP 2007
- Deutsche Forschungsgemeinschaft. Grant Number: 113/13-3
- Köln Fortune, Germany
- Brain Tumour Net
Coronin-3 (coronin-1C), a homotrimeric F-actin binding protein, has been shown to be important for cell migration and brain morphogenesis. Here, we present for the first time a detailed analysis of the expression pattern of coronin-3 in human brain tumours and demonstrate that coronin-3 expression correlates with malignant phenotype in diffuse gliomas. In general, the expression of coronin-3 varies in different brain tumour entities. However, in diffuse gliomas, the number of coronin-3 expressing tumour cells correlates with the degree of malignancy. High-grade gliomas, such as anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic oligoastrocytomas and glioblastomas, show high numbers of tumour cells positive for coronin-3, while diffuse low-grade gliomas, such as diffuse astrocytomas, oligodendrogliomas and oligoastrocytomas, exhibit low numbers of coronin-3-positive tumour cells. In order to explore and verify a contribution of coronin-3 to the malignant phenotype of diffuse gliomas, we employed an efficient shRNA-mediated coronin-3 knockdown in U373 and A172 human glioblastoma cells. Coronin-3 knockdown glioblastoma cells exhibited reduced levels of cell proliferation, cell motility and invasion into extracellular matrix compared to control cells. Together, our findings demonstrate evidence for a contribution of coronin-3 expression in the malignant progression of diffuse gliomas. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.