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Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions

Authors

  • AS Savchenko,

    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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  • M Imamura,

    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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  • R Ohashi,

    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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  • S Jiang,

    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    2. Perseus Proteomics Inc, Tokyo, Japan
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  • T Kawasaki,

    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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  • G Hasegawa,

    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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  • I Emura,

    1. Department of Surgical Pathology, Nagaoka Red Cross Hospital, Nagaoka, Japan
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  • H Iwanari,

    1. Perseus Proteomics Inc, Tokyo, Japan
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  • M Sagara,

    1. Perseus Proteomics Inc, Tokyo, Japan
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  • T Tanaka,

    1. Laboratory for Systemic Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
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  • T Hamakubo,

    1. Laboratory for Systemic Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
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  • T Kodama,

    1. Laboratory for Systemic Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
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  • M Naito

    Corresponding author
    1. Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    • Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, Chuou, Niigata 951-8510, Japan.
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  • No conflicts of interest were declared.

Abstract

Pentraxin 3 (PTX3) and C-reactive protein (CRP) are members of the pentraxin superfamily. PTX3 expression is induced in response to inflammatory signals, and is produced at sites of inflammation by several types of cell, primarily monocytes/macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells (SMCs), and fibroblasts, but is not produced by hepatocytes, which are a major source of CRP. The aim of our study was to investigate the expression pattern of PTX3 in human atherosclerotic lesions using a novel monoclonal antibody against PTX3. We examined coronary arterial thrombi containing an atherosclerotic plaque component removed from patients with acute myocardial infarction and human aortic tissues with various degrees of atherosclerosis sampled from autopsy cases. Immunohistochemical study of paraffin and frozen sections indicated that macrophages, mainly foam cells, expressed PTX3 in advanced atherosclerotic lesions. Interestingly, we also clearly observed PTX3-positive neutrophils infiltrating into atherosclerotic plaques, suggesting that PTX3 derived from neutrophils as well as macrophages plays an important role in atherogenesis. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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