Conflict of interest statement: GIM is a named inventor on a patent application made by the University of Aberdeen to exploit the over-expression in colorectal cancer of proteins, including annexin A4 as diagnostic markers and therapeutic targets.
The role of annexins in tumour development and progression†
Article first published online: 14 JUL 2008
Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 216, Issue 2, pages 131–140, October 2008
How to Cite
Mussunoor, S. and Murray, G. (2008), The role of annexins in tumour development and progression. J. Pathol., 216: 131–140. doi: 10.1002/path.2400
- Issue published online: 2 SEP 2008
- Article first published online: 14 JUL 2008
- Accepted manuscript online: 14 JUL 2008 12:00AM EST
- Manuscript Accepted: 24 JUN 2008
- Manuscript Revised: 19 JUN 2008
- Manuscript Received: 26 MAR 2008
- Association for International Cancer Research
- University of Aberdeen Development Trust
The annexins are a super-family of closely related calcium and membrane-binding proteins. They have a diverse range of cellular functions that include vesicle trafficking, cell division, apoptosis, calcium signalling and growth regulation. Many studies have shown the annexins to be among the genes whose expression are consistently differentially altered in neoplasia. Some annexins show increased expression in specific types of tumours, while others show loss of expression. Mechanistic studies relating the changes in annexin expression to tumour cell function, particularly tumour invasion and metastasis, angiogenesis and drug resistance, are now also emerging. Changes in the expression of individual annexins are associated with particular types of tumour and hence the annexins may also be useful biomarkers in the clinic. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.