Epidermal stem cells: location, potential and contribution to cancer
Article first published online: 14 OCT 2008
Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: Stem cells in pathobiology and regenerative medicine
Volume 217, Issue 2, pages 206–216, January 2009
How to Cite
Ambler, C. and Määttä, A. (2009), Epidermal stem cells: location, potential and contribution to cancer. J. Pathol., 217: 206–216. doi: 10.1002/path.2468
- Issue published online: 16 DEC 2008
- Article first published online: 14 OCT 2008
- Accepted manuscript online: 14 OCT 2008 12:00AM EST
- stem cell;
Epidermal stem cells have been classically characterized as slow-cycling, long-lived cells that reside in discrete niches in the skin. Gene expression studies of niche-resident cells have revealed a number of stem cell markers and regulators, including the Wnt/β-catenin, Notch, p63, c-Myc and Hedgehog pathways. A new study challenges the traditional developmental paradigm of slow-cycling stem cells and rapid-cycling transit amplifying cells in some epidermal regions, and there is mounting evidence to suggest that multi-lineage epidermal progenitors can be isolated from highly proliferative, non-niche regions. Whether there is a unique microenvironment surrounding these progenitors remains to be determined. Interestingly, cancer stem cells derived from epidermal tumours exist independent of the classic skin stem cell niche, yet also have stem cell properties, including multi-lineage differentiation. This review summarizes recent studies identifying the location and regulators of mouse and human epidermal stem cells and highlights the strategies used to identify cancer stem cells, including expression of normal epidermal stem cell markers, expression of cancer stem cell markers identified in other epidermal tumours and characterization of side-population tumour cells. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.