No conflicts of interest were declared.
Endogenous lung stem cells and contribution to disease†
Article first published online: 16 OCT 2008
Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: Stem cells in pathobiology and regenerative medicine
Volume 217, Issue 2, pages 254–264, January 2009
How to Cite
Snyder, J., Teisanu, R. and Stripp, B. (2009), Endogenous lung stem cells and contribution to disease. J. Pathol., 217: 254–264. doi: 10.1002/path.2473
- Issue published online: 16 DEC 2008
- Article first published online: 16 OCT 2008
- Accepted manuscript online: 16 OCT 2008 12:00AM EST
- NIH. Grant Numbers: ES008964, HL064888, HL090146
- stem cells;
Epithelial branching during the process of lung development results in the establishment of distinct functional zones, each of which is characterized by a unique cellular composition and repertoire of local progenitor cells. Significant new insights into cellular and molecular mechanisms of epithelial maintenance that provide insights into the pathophysiology of lung disease have been made in recent years. This review focuses on the complex structure–function relationship in the airway epithelium, how this epithelium is maintained in the normal state and repaired following injury, and how deregulation may contribute to airway disease and cancer. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.