No conflicts of interest were declared.
Recent progress in understanding the pathology of malignant melanoma†
Article first published online: 25 AUG 2009
Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 219, Issue 4, pages 400–409, December 2009
How to Cite
Kuphal, S. and Bosserhoff, A. (2009), Recent progress in understanding the pathology of malignant melanoma. J. Pathol., 219: 400–409. doi: 10.1002/path.2617
- Issue published online: 9 NOV 2009
- Article first published online: 25 AUG 2009
- Accepted manuscript online: 25 AUG 2009 12:00AM EST
- Manuscript Accepted: 16 AUG 2009
- Manuscript Revised: 22 JUL 2009
- Manuscript Received: 8 JUN 2009
- German Cancer Foundation (German Melanoma Network)
- Wilhelm Sander Foundation
- stem cell marker;
- mesenchymal-elongated-type and rounded-amoeboid mode of movement;
Recently, several important findings on melanoma development and progression have accelerated progress towards a molecular understanding of melanoma biology. Furthermore, the development of experimental tools, such as a wide range of cell lines and animal models of metastasis, has turned melanoma into a model for general tumour research. However, it has also become evident that melanoma is distinct from other tumours with regard to its cellular origin and pathophysiological mechanisms. This review focuses on important new findings that have contributed to a greater understanding of the molecular processes leading to melanoma. Translating these innovative new results into potent therapeutic approaches will require even more effort. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.