No conflicts of interest were declared.
Does massively parallel DNA resequencing signify the end of histopathology as we know it?†
Article first published online: 17 NOV 2009
Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: Genes, Genomes and Disease
Volume 220, Issue 2, pages 307–315, January 2010
How to Cite
Aparicio, S. A. and Huntsman, D. G. (2010), Does massively parallel DNA resequencing signify the end of histopathology as we know it?. J. Pathol., 220: 307–315. doi: 10.1002/path.2636
- Issue published online: 7 DEC 2009
- Article first published online: 17 NOV 2009
- Manuscript Accepted: 26 SEP 2009
- Manuscript Revised: 23 SEP 2009
- Manuscript Received: 1 SEP 2009
- DNA sequencing;
- mutational heterogeneity;
- cancer genome;
- tissue sampling;
- mutational landscape;
- tumour evolution
Next-generation DNA sequencing devices have revolutionized cancer genomics by bringing whole genome resequencing of patients' tumours within practical and economic reach. We present an overview of the techniques involved and review early results from the resequencing of cancer genomes. The possible impacts of whole-genome and trancriptome resequencing in clinical cancer research and the practice of pathology are discussed. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.