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Does massively parallel DNA resequencing signify the end of histopathology as we know it?†

  1. Samuel AJR Aparicio1,2,3,*,
  2. David G Huntsman2,3

Article first published online: 17 NOV 2009

DOI: 10.1002/path.2636

Issue

The Journal of Pathology

The Journal of Pathology

Special Issue: Genes, Genomes and Disease

Volume 220, Issue 2, pages 307–315, January 2010

Additional Information

How to Cite

Aparicio, S. A. and Huntsman, D. G. (2010), Does massively parallel DNA resequencing signify the end of histopathology as we know it?. J. Pathol., 220: 307–315. doi: 10.1002/path.2636

Author Information

  1. 1

    Molecular Oncology, BC Cancer Agency, 675 W10th Avenue, Vancouver V5Z 1L3, Canada

  2. 2

    Centre for Translational and Applied Genomics, BC Cancer Agency, Vancouver V5Z 1L3, Canada

  3. 3

    Department of Pathology, University of British Columbia, G227-2211 Wesbrook Mall, Vancouver, BC V6T 2B5 Canada

*Molecular Oncology, BC Cancer Agency, 675 W10th Avenue, Vancouver V5Z 1L3, Canada.

  1. †

    No conflicts of interest were declared.

Publication History

  1. Issue published online: 7 DEC 2009
  2. Article first published online: 17 NOV 2009
  3. Manuscript Accepted: 26 SEP 2009
  4. Manuscript Revised: 23 SEP 2009
  5. Manuscript Received: 1 SEP 2009

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Keywords:

  • DNA sequencing;
  • mutational heterogeneity;
  • cancer genome;
  • transcriptome;
  • tissue sampling;
  • mutational landscape;
  • tumour evolution

Abstract

Next-generation DNA sequencing devices have revolutionized cancer genomics by bringing whole genome resequencing of patients' tumours within practical and economic reach. We present an overview of the techniques involved and review early results from the resequencing of cancer genomes. The possible impacts of whole-genome and trancriptome resequencing in clinical cancer research and the practice of pathology are discussed. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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