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Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary†

  1. Ahmed Ashour Ahmed1,2,
  2. Dariush Etemadmoghadam3,
  3. Jillian Temple1,2,
  4. Andy G Lynch2,
  5. Mohamed Riad Australian Ovarian Cancer Study Group4,
  6. Raghwa Sharma5,
  7. Colin Stewart6,
  8. Sian Fereday3,
  9. Carlos Caldas2,7,
  10. Anna deFazio8,
  11. David Bowtell3,9,*,
  12. James D Brenton1,2,*

Article first published online: 3 FEB 2010

DOI: 10.1002/path.2696

Issue

The Journal of Pathology

The Journal of Pathology

Volume 221, Issue 1, pages 49–56, May 2010

Additional Information

How to Cite

Ahmed, A. A., Etemadmoghadam, D., Temple, J., Lynch, A. G., Riad, M., Sharma, R., Stewart, C., Fereday, S., Caldas, C., deFazio, A., Bowtell, D. and Brenton, J. D. (2010), Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J. Pathol., 221: 49–56. doi: 10.1002/path.2696

Author Information

  1. 1

    Functional Genomics of Ovarian Cancer Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK

  2. 2

    Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK

  3. 3

    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

  4. 4

    Department of Obstetrics and Gynaecology, El-Galaa Maternity Teaching Hospital, 41 July 26th Street, Cairo 11511, Egypt

  5. 5

    Department of Anatomical Pathology, University of Sydney and University of Western Sydney at Westmead Hospital, Sydney, Australia

  6. 6

    Department of Pathology, King Edward Memorial Hospital, Western Australia, Australia

  7. 7

    Functional Genomics of Breast Cancer Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK

  8. 8

    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, New South Wales, Australia

  9. 9

    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia

*Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, 8006, Victoria, Australia.

  1. †

    No conflicts of interest were declared.

Publication History

  1. Issue published online: 1 APR 2010
  2. Article first published online: 3 FEB 2010
  3. Accepted manuscript online: 3 FEB 2010 12:00AM EST
  4. Manuscript Accepted: 26 JAN 2010
  5. Manuscript Revised: 24 JAN 2010
  6. Manuscript Received: 9 DEC 2009

Funded by

  • University of Cambridge
  • NIHR Cambridge Biomedical Research Centre
  • Cambridge Experimental Cancer Medicine Centre
  • US Army Medical Research and Material Command. Grant Number: DAMD17-01-1-0729
  • Cancer Council Victoria
  • Queensland Cancer Fund
  • Cancer Council New South Wales
  • Cancer Council South Australia
  • Cancer Foundation of Western Australia
  • Cancer Council Tasmania
  • NH&MRC
  • Cancer Research UK (CR-UK)
  • Medical Research Council (MRC)
  • National Health and Medical Research Council of Australia (NHMRC)
  • Re-use of this article is permitted in accordance with the Terms and Conditions set out at . [http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms]

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FilenameFormatSizeDescription
PATH2696_Supplementary_Table_1.pdf158KSupporting Information: Samples listed by AOCS number with results of somatic TP53 sequencing.
path_2696_sm_suppinfos2.pdf98KSupporting Information: Summary of clinical, pathology and molecular review of mutation-negative serous carcinomas.
path_2696_sm_suppinfos3.pdf48KSupporting Information: Summary of all cases included in the pilot and validation sets.
path_2696_sm_suppinfos4.doc101KSupporting Information: Supplementary experimental procedures.

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