These authors contributed equally to this work.
AMP-activated protein kinase: ‘a cup of tea’ against cholesterol-induced neurotoxicity†
Article first published online: 4 OCT 2010
Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 222, Issue 4, pages 329–334, December 2010
How to Cite
Martínez de Morentin, P. B., González, C. R. and López, M. (2010), AMP-activated protein kinase: ‘a cup of tea’ against cholesterol-induced neurotoxicity. J. Pathol., 222: 329–334. doi: 10.1002/path.2778
No conflicts of interest were declared.
- Issue published online: 25 OCT 2010
- Article first published online: 4 OCT 2010
- Accepted manuscript online: 15 SEP 2010 12:00AM EST
- Manuscript Accepted: 7 SEP 2010
- Manuscript Received: 16 AUG 2010
- Manuscript Revised: 16 AUG 2010
- Fondo Investigaciones Sanitarias. Grant Number: ML: PS09/01880
- Ministerio de Ciencia e Innovación. Grant Number: ML: RyC-2007-00211
Disturbances in brain cholesterol metabolism have been linked to Alzheimer's disease (AD) pathology. A high-cholesterol diet increases fibrillar amyloid β peptide (Aβ) deposition, inflammation, and apoptosis that eventually results in neurodegeneration and learning and memory impairments. In the October 2010 issue of The Journal of Pathology, Lu and colleagues provided a novel and interesting mechanism that explains how quercetin, a flavonoid found at high concentrations in green and black teas, may help to protect against cholesterol-induced neurotoxicity through activation of AMP-activated protein kinase (AMPK), a metabolic energy gauge. Further work will be necessary to address whether AMPK may be a potential target to combat neurodegenerative diseases. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Invited Commentary for Lu et al. Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity, Journal of Pathology, 2010; 222 199–212.