No conflicts of interest were declared.
Tracing the origins of metastasis†
Article first published online: 29 OCT 2010
Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: Cancer Biology and Genomics
Volume 223, Issue 2, pages 196–205, January 2011
How to Cite
Nguyen, D. X. (2011), Tracing the origins of metastasis. J. Pathol., 223: 196–205. doi: 10.1002/path.2801
- Issue published online: 2 DEC 2010
- Article first published online: 29 OCT 2010
- Accepted manuscript online: 6 OCT 2010 07:38AM EST
- Manuscript Accepted: 30 SEP 2010
- Manuscript Revised: 29 SEP 2010
- Manuscript Received: 2 AUG 2010
- American Cancer Society
- Uniting Against Lung Cancer
- V Foundation (to DXN)
- cancer stem cells;
- tumour heterogeneity;
Cancer metastasis is often considered an orderly sequence of events leading to the colonization of distal organs by malignant cells. In fact, the evolution of metastatic disease is a dynamic process that is influenced by unique cellular lineages, altered microenvironments, distinct anatomical restrictions and multiple genetic and epigenetic alterations. These factors all contribute to variable clinical courses, likely requiring tailored therapy. As we inch closer towards personalized medicine, there is a renewed conceptual and technological focus on characterizing the cellular and genetic heterogeneity within tumours, to ultimately trace the origins of metastatic cells in different cancers. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.