Original Paper

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Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma†

  1. Kue Peng Lim1,2,
  2. Nicola Cirillo1,
  3. Yazan Hassona1,
  4. Wenbin Wei3,
  5. Johanna K Thurlow4,
  6. Sok Ching Cheong2,
  7. Gayani Pitiyage5,
  8. E Ken Parkinson5,
  9. Stephen S Prime1,*

Article first published online: 17 JAN 2011

DOI: 10.1002/path.2841

Issue

The Journal of Pathology

The Journal of Pathology

Volume 223, Issue 4, pages 459–469, March 2011

Additional Information

How to Cite

Lim, K. P., Cirillo, N., Hassona, Y., Wei, W., Thurlow, J. K., Cheong, S. C., Pitiyage, G., Parkinson, E. K. and Prime, S. S. (2011), Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma. J. Pathol., 223: 459–469. doi: 10.1002/path.2841

Author Information

  1. 1

    School of Oral and Dental Sciences, University of Bristol, UK

  2. 2

    Cancer Research Initiatives Foundation, Sime Darby, Subang Jaya Medical Centre, 47500 Subang Jaya, Selangor, Malaysia

  3. 3

    Birmingham CRUK Centre, University of Birmingham, UK

  4. 4

    Beatson Institute for Cancer Research, Glasgow, UK

  5. 5

    Department of Clinical and Diagnostic Oral Sciences, Queen Mary's School of Medicine and Dentistry, Institute of Cell and Molecular Sciences, London, UK

*Bristol Dental Hospital and School, Lower Maudlin Street, Bristol, BS1 2LY, UK.

  1. †

    No conflicts of interest were declared.

Publication History

  1. Issue published online: 3 FEB 2011
  2. Article first published online: 17 JAN 2011
  3. Accepted manuscript online: 9 DEC 2010 08:00AM EST
  4. Manuscript Accepted: 29 NOV 2010
  5. Manuscript Revised: 28 NOV 2010
  6. Manuscript Received: 20 OCT 2010

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FilenameFormatSizeDescription
path2841_suppinfots1.xls115KSupporting Information: Table S1. List of genes differentially expressed in fibroblasts from genetically unstable OSCC versus normal oral mucosa.
path2841_suppinfots2.xls63KSupporting Information: Table S2. List of genes differentially expressed in fibroblasts from genetically unstable OSCC versus genetically stable OSCC.
path2841_suppinfots3.xls58KSupporting Information: Table S3. List of genes differentially expressed in fibroblasts from genetically stable OSCC versus normal oral mucosa.
path2841_suppinfots4.xls88KSupporting Information: Table S4. Transcriptome–interactome analysis.
path2841_suppinfots5.xls61KSupporting Information: Table S5. The up-regulated DTGs, including genes differentially expressed in fibroblasts from unstable OSCC versus normal oral mucosa (1), stable OSCC versus normal oral mucosa (2), and genetically unstable OSCC versus genetically stable OSCC (3), were correlated with clinical outcome in an independent microarray database 27 of whole tissue samples of HNSCC (61 primaries, eight recurrences, and two second primaries) and 14 normal oral mucosa.
path2841_suppinfofs1.doc44KSupporting Information: Figure S1. Pearson's r correlation between connectivity and DTGs in the different fibroblast strains (normal oral mucosa, genetically stable and unstable OSCC) is reported.
path2841_suppinfolege.doc26KSupporting Information: Legends to Table S1 to S7 and Figure S1
path2841_suppinfometerials.doc28KSupporting Information: Supplementary materials and methods

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View Full Article with Supporting Information (HTML) Get PDF (433K)