No conflicts of interest were declared.
Article first published online: 4 JUL 2011
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 224, Issue 4, pages 431–433, August 2011
How to Cite
Looijenga, L. H. (2011), Spermatocytic seminoma: toward further understanding of pathogenesis. J. Pathol., 224: 431–433. doi: 10.1002/path.2939
Invited commentary for Lim J, Goriely A, Turner G, et al. OCT2, SSX and SAGE1 reveal the phenotypic hetereogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. J Pathol 2011; 224: 473-483; DOI: 10.1002/path.2919.
- Issue published online: 4 JUL 2011
- Article first published online: 4 JUL 2011
- Accepted manuscript online: 16 MAY 2011 12:00AM EST
- Manuscript Accepted: 5 MAY 2011
- Manuscript Received: 19 APR 2011
- Manuscript Revised: 19 APR 2011
- germ cell tumours;
- spermatocytic seminoma;
- expression profiling;
Human germ cell tumours comprise a heterogeneous group of neoplasms which, based on pathobiological, genetic and clinical characteristics, can be subdivided into different entities. One of these subgroups relates to the so-called spermatocytic seminomas, benign tumours only found in the testis, preferentially in elderly men. Various developmental models for this type of germ cell tumour have been proposed and it is clear that spermatocytic seminoma has a pathogenesis independent from that of seminoma. A recent study examining expression of spermatogonial markers shows that spermatocytic seminomas are a heterogeneous group of tumours, with a supposed difference in origin, ie the majority from A or B spermatogonia, and a minority from A spermatogonia. However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.