Notch in the kidney: development and disease

Authors

  • Yasemin Sirin,

    1. Department of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
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  • Katalin Susztak

    Corresponding author
    1. Department of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    2. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA
    • Division of Nephrology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
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  • No conflicts of interest were declared.

Abstract

Notch signalling is a highly conserved cell–cell communication mechanism that regulates development, tissue homeostasis, and repair. Within the kidney, Notch has an important function in orchestrating kidney development. Recent studies indicate that Notch plays a key role in establishing proximal epithelial fate during nephron segmentation as well as the differentiation of principal cells in the renal collecting system. Notch signalling is markedly reduced in the adult kidney; however, increased Notch signalling has been noted in both acute and chronic kidney injury. Increased glomerular epithelial Notch signalling has been associated with albuminuria and glomerulosclerosis, while tubular epithelial Notch activation caused fibrosis development most likely inducing an improper epithelial repair pathway. Recent studies thereby indicate that Notch is a key regulator of kidney development, repair, and injury. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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