Original Paper

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction †

  1. Alvin J. X. Lee1,
  2. Rebecca Roylance2,
  3. Jil Sander1,3,
  4. Patricia Gorman2,
  5. David Endesfelder1,3,
  6. Maik Kschischo3,
  7. Neil P. Jones4,
  8. Philip East1,
  9. Barbara Nicke1,
  10. Stefka Spassieva5,
  11. Lina M. Obeid5,6,
  12. Nicolai Juul Birkbak7,8,
  13. Zoltan Szallasi7,9,
  14. Nicole C. McKnight1,
  15. Andrew J. Rowan1,
  16. Valerie Speirs10,
  17. Andrew M. Hanby10,
  18. Julian Downward1,
  19. Sharon A. Tooze1,
  20. Charles Swanton1,11,*

Article first published online: 19 OCT 2011

DOI: 10.1002/path.2998

Issue

The Journal of Pathology

The Journal of Pathology

Volume 226, Issue 3, pages 482–494, February 2012

Additional Information

How to Cite

Lee, A. J. X., Roylance, R., Sander, J., Gorman, P., Endesfelder, D., Kschischo, M., Jones, N. P., East, P., Nicke, B., Spassieva, S., Obeid, L. M., Birkbak, N. J., Szallasi, Z., McKnight, N. C., Rowan, A. J., Speirs, V., Hanby, A. M., Downward, J., Tooze, S. A. and Swanton, C. (2012), CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction . J. Pathol., 226: 482–494. doi: 10.1002/path.2998

Author Information

  1. 1

    Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK

  2. 2

    Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

  3. 3

    University of Applied Sciences Koblenz, RheinAhrCampus, Südallee 2, 53424 Remagen, Germany

  4. 4

    Cancer Research Technology, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK

  5. 5

    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA

  6. 6

    Division of General Internal Medicine, Ralph H. Johnson Veterans Affairs Hospital, Charleston, SC 29401, USA

  7. 7

    Centre for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark

  8. 8

    Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA

  9. 9

    Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA

  10. 10

    Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK

  11. 11

    UCL Cancer Institute and Macmillan Cancer Centre, Huntley Street, London WC1E 6BT, UK

*Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK..

  1. †

    No conflicts of interest were declared.

Publication History

  1. Issue published online: 16 JAN 2012
  2. Article first published online: 19 OCT 2011
  3. Accepted manuscript online: 26 SEP 2011 04:46AM EST
  4. Manuscript Accepted: 8 SEP 2011
  5. Manuscript Revised: 5 SEP 2011
  6. Manuscript Received: 24 JUL 2011

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