No conflicts of interest were declared.
Anoikis: an emerging hallmark in health and diseases†
Article first published online: 1 DEC 2011
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: The Cell Biology of Disease
Volume 226, Issue 2, pages 380–393, January 2012
How to Cite
Taddei, M., Giannoni, E., Fiaschi, T. and Chiarugi, P. (2012), Anoikis: an emerging hallmark in health and diseases. J. Pathol., 226: 380–393. doi: 10.1002/path.3000
- Issue published online: 1 DEC 2011
- Article first published online: 1 DEC 2011
- Accepted manuscript online: 26 SEP 2011 04:46AM EST
- Manuscript Accepted: 15 SEP 2011
- Manuscript Revised: 31 AUG 2011
- Manuscript Received: 29 JUL 2011
- anoikis resistance;
- cardiovascular diseases;
Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix. Anoikis prevents detached epithelial cells from colonizing elsewhere and is thus essential for tissue homeostasis and development. As anchorage-independent growth and epithelial–mesenchymal transition, two features associated with anoikis resistance, are crucial steps during tumour progression and metastatic spreading of cancer cells, anoikis deregulation has now evoked particular attention from the scientific community. The aim of this review is to analyse the molecular mechanisms governing both anoikis and anoikis resistance, focusing on their regulation in physiological processes, as well as in several diseases, including metastatic cancers, cardiovascular diseases and diabetes. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.