No conflicts of interest were declared.
Cytokinesis, ploidy and aneuploidy†
Article first published online: 14 NOV 2011
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: The Cell Biology of Disease
Volume 226, Issue 2, pages 338–351, January 2012
How to Cite
Lacroix, B. and Maddox, A. S. (2012), Cytokinesis, ploidy and aneuploidy. J. Pathol., 226: 338–351. doi: 10.1002/path.3013
- Issue published online: 1 DEC 2011
- Article first published online: 14 NOV 2011
- Accepted manuscript online: 7 OCT 2011 08:31AM EST
- Manuscript Accepted: 24 SEP 2011
- Manuscript Revised: 22 SEP 2011
- Manuscript Received: 2 AUG 2011
- cell division;
- contractile ring;
Cytokinesis is the last step of cell division that physically separates the daughter cells. As such, it ensures the proper inheritance of both nuclear and cytoplasmic contents. Accomplishment of cytokinesis in eukaryotes is dictated by several key events: establishment of the division plane, furrow ingression through contraction of an actomyosin ring and abscission via membrane fusion. Most mammalian somatic cells are diploid. Polyploidy can result from cytokinesis failure and may contribute to the development of pathologies such as cancer. However, polyploidy is essential for cellular differentiation and function in some contexts (eg hepatocytes, megakaryocytes and others). Consequently, the degree of ploidy and the achievement of cytokinesis must be tightly regulated throughout an organism and among different cell types. In this review we will highlight several examples of normal and pathological polyploidy, focusing on those caused by a controlled failure or dysregulation of cytokinesis, respectively. Last, we propose therapeutic routes to control cytokinesis to restore or block cell division. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.