No conflicts of interest were declared.
Cell–matrix interactions in muscle disease†
Article first published online: 1 DEC 2011
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: The Cell Biology of Disease
Volume 226, Issue 2, pages 200–218, January 2012
How to Cite
Carmignac, V. and Durbeej, M. (2012), Cell–matrix interactions in muscle disease. J. Pathol., 226: 200–218. doi: 10.1002/path.3020
- Issue published online: 1 DEC 2011
- Article first published online: 1 DEC 2011
- Accepted manuscript online: 12 OCT 2011 05:26AM EST
- Manuscript Accepted: 1 OCT 2011
- Manuscript Revised: 28 SEP 2011
- Manuscript Received: 27 JUL 2011
- extracellular matrix;
- muscular dystrophy
The extracellular matrix (ECM) provides a solid scaffold and signals to cells through ECM receptors. The cell–matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of ECM–cell membrane–cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these interactions. In this review we introduce laminins, collagens, dystroglycan, integrins, dystrophin and sarcoglycans. Mutations in corresponding genes cause various forms of muscular dystrophy. The muscle disorders are presented as well as advances toward the development of treatment. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.