No conflicts of interest were declared.
The cell cycle and cancer†
Article first published online: 28 OCT 2011
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: The Cell Biology of Disease
Volume 226, Issue 2, pages 352–364, January 2012
How to Cite
Williams, G. H. and Stoeber, K. (2012), The cell cycle and cancer. J. Pathol., 226: 352–364. doi: 10.1002/path.3022
- Issue published online: 1 DEC 2011
- Article first published online: 28 OCT 2011
- Accepted manuscript online: 12 OCT 2011 05:26AM EST
- Manuscript Accepted: 1 OCT 2011
- Manuscript Revised: 30 SEP 2011
- Manuscript Received: 17 AUG 2011
- cell cycle;
- DNA replication;
Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past two decades, cancer genetics has shown that hyperactivating mutations in growth signalling networks, coupled to loss of function of tumour suppressor proteins, drives oncogenic proliferation. Gene expression profiling of these complex and redundant mitogenic pathways to identify prognostic and predictive signatures and their therapeutic targeting has, however, proved challenging. The cell cycle machinery, which acts as an integration point for information transduced through upstream signalling networks, represents an alternative target for diagnostic and therapeutic interventions. Analysis of the DNA replication initiation machinery and mitotic engine proteins in human tissues is now leading to the identification of novel biomarkers for cancer detection and prognostication, and is providing target validation for cell cycle-directed therapies. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.