Conflict of interest. The author has a current research project in her laboratory relating to a chemokine receptor that is funded by Affitech AS.
The chemokine system and cancer†
Article first published online: 23 NOV 2011
Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Special Issue: The Cell Biology of Disease
Volume 226, Issue 2, pages 148–157, January 2012
How to Cite
Balkwill, F. R. (2012), The chemokine system and cancer. J. Pathol., 226: 148–157. doi: 10.1002/path.3029
- Issue published online: 1 DEC 2011
- Article first published online: 23 NOV 2011
- Accepted manuscript online: 12 OCT 2011 05:27AM EST
- Manuscript Revised: 5 OCT 2011
- Manuscript Accepted: 5 OCT 2011
- Manuscript Received: 15 SEP 2011
- tumour-associated macrophages;
Chemokines (chemo-attractant cytokines) are a group of small proteins that act together with their cell surface receptors, in development, normal physiology and immune responses, to direct cells to specific locations throughout the body. Cancer cells acquire the ability to subvert the chemokine system, such that these molecules and their receptors become important regulators of cell movement into and out of the tumour microenvironment and major players in cancer biology. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.