Invited commentary for: Fornari F, Milazzo M, Chieco P, et al. In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. J Pathol 2012; 227: 275–285.
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Invited Commentary
Article first published online: 30 APR 2012
DOI: 10.1002/path.4014
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Additional Information
How to Cite
Flor, I. and Bullerdiek, J. (2012), The dark side of a success story: microRNAs of the C19MC cluster in human tumours. J. Pathol., 227: 270–274. doi: 10.1002/path.4014
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No conflicts of interest were declared.
Publication History
- Issue published online: 6 JUN 2012
- Article first published online: 30 APR 2012
- Accepted manuscript online: 28 FEB 2012 11:31AM EST
- Manuscript Accepted: 21 FEB 2012
- Manuscript Received: 7 FEB 2012
- Manuscript Revised: 7 FEB 2012
- Abstract
- Article
- References
- Cited By
Keywords:
- microRNAs;
- C19MC;
- epigenetic control;
- placenta;
- tumourigenesis
Abstract
MicroRNAs are a class of macromolecules of rapidly emerging significance for the pathogenesis of numerous human diseases, including cancer. Moreover, many of them hold great promise as valid biomarkers because of their high extracellular stability. Chromosome 19 harbours the largest cluster of microRNA genes known so far, which has developed in a very short time during mammalian evolution. Thus, in terms of evolution, gain of this cluster is an apparent success story. Nevertheless, we know very little about how functions of its microRNAs have contributed to this success and apparently, at least some of them can turn from Jekyll into Hyde and contribute to tumourigenesis. Recent work published in the Journal of Pathology by Fornari and colleagues, addressed here, reveals how members of that cluster are involved in the molecular pathogenesis of hepatocellular carcinomas. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.