Joint last authors.
Original Paper
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Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts†
Article first published online: 23 MAY 2012
DOI: 10.1002/path.4034
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Additional Information
How to Cite
Simpkins, S. A., Hanby, A. M., Holliday, D. L. and Speirs, V. (2012), Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts. J. Pathol., 227: 490–498. doi: 10.1002/path.4034
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No conflicts of interest were declared.
- ‡
Joint last authors.
Publication History
- Issue published online: 10 JUL 2012
- Article first published online: 23 MAY 2012
- Accepted manuscript online: 4 APR 2012 07:03AM EST
- Manuscript Accepted: 29 MAR 2012
- Manuscript Revised: 9 FEB 2012
- Manuscript Received: 3 NOV 2011
References
- 1, . Fibroblasts in cancer. Nature Rev Cancer 2006; 6: 392–401.
- 2, . Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Gen Dev 2001; 11: 54–59.
- 3, , , et al. Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues. Int J Cancer 1988; 41: 707–712.
- 4, , , et al. Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci U S A 1993; 90: 999–1003.
- 5, . Friends or foes—bipolar effects of the tumour stroma in cancer. Nature Rev Cancer 2004; 4: 839–849.
- 6, , . Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996; 76: 69–125.
- 7
- 8, , , et al. Role of caveolae and caveolins in health and disease. Physiol Rev 2004; 84: 1341–1379.
- 9, , , et al. An absence of stromal caveolin-1 expression predicts early tumour recurrence and poor clinical outcome in human breast cancers. Am J Pathol 2009; 174: 2023–2034.
- 10, , , et al. Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol 2009; 174: 2035–2043.
- 11, , , et al. Prognostic significance of tumour/stromal caveolin-1 expression in breast cancer patients. Cancer Sci 2011; 102: 1590–1596.
- 12, , , et al. The impact of caveolin protein expression in tumour stroma on prognosis in breast cancer. Tumor Biol 2011; 32: 787–799.
- 13, , . Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumour recurrence and clinical outcome. Pathol Oncol Res 2012; 18: 459–469.
- 14, , , et al. Transplantation of colon carcinoma into granulation tissue induces an invasive morphotype. Int J Cancer 1993; 54: 1010–1016.
- 15, , , et al. Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival. Cell Cycle 2011; 10: 4250–4255.
- 16, , , et al. Caveolin-1 − /− null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol 2009; 174: 746–761.
- 17, , , et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumour stroma. Cell Cycle 2009; 8: 3984–4001.
- 18, , . Caveolin-1 in breast cancer. Cancer Biol Ther 2004; 3: 931–941.
- 19, , , et al. Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci U S A 2001; 98: 646–651.
- 20, , , et al. Breast cell invasive potential relates to the myoepithelial phenotype. Int J Cancer 2003; 106: 8–16.
- 21, , , et al. Intrinsic genetic characteristics determine tumour-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion. Breast Cancer Res 2007; 9:: R67.
- 22, , , et al. Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression. Breast Cancer Res 2009; 11: R3.
- 23, , , et al. Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol 2009; 175: 334–341.
- 24, , , et al. Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade. Mod Pathol 2007; 20: 84–89.
- 25, , , et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999; 277: 1–9.
- 26, , . Caveolin-1 in breast cancer. Cancer Biol Ther 2004; 3: 931–941.
- 27, , , et al. Molecular profiling of a lethal tumour microenvironment, as defined by stromal caveolin-1 status in breast cancers. Cell Cycle 2011; 10: 1794–809.
- 28, , , et al. Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumour suppressor functional inactivation: implications for the response to hormonal therapy. Cancer Biol Ther 2008; 7: 1212–1225.
- 29, , , et al. Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers. Cancer Biol Ther 2010; 10: 135–143.
- 30, , , et al. Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer. Cancer Biol Ther 2009; 8: 1071–1079.

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