Original Paper

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Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts†

  1. Samantha A Simpkins,
  2. Andrew M Hanby,
  3. Deborah L Holliday‡,
  4. Valerie Speirs‡,*

Article first published online: 23 MAY 2012

DOI: 10.1002/path.4034

Issue

The Journal of Pathology

The Journal of Pathology

Volume 227, Issue 4, pages 490–498, August 2012

Additional Information

How to Cite

Simpkins, S. A., Hanby, A. M., Holliday, D. L. and Speirs, V. (2012), Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts. J. Pathol., 227: 490–498. doi: 10.1002/path.4034

Author Information

  1. Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK

  1. ‡

    Joint last authors.

*Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK.

  1. †

    No conflicts of interest were declared.

  2. ‡

    Joint last authors.

Publication History

  1. Issue published online: 10 JUL 2012
  2. Article first published online: 23 MAY 2012
  3. Accepted manuscript online: 4 APR 2012 07:03AM EST
  4. Manuscript Accepted: 29 MAR 2012
  5. Manuscript Revised: 9 FEB 2012
  6. Manuscript Received: 3 NOV 2011

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path_4034_sm_supportinginformationsfs1.tif1485KSupporting Information: Figure S1. Immunofluorescent characterization of primary fibroblasts showed that over 95% of cells exhibited staining for vimentin (A) but were uniformly negative for cytokeratin 18 (B), cytokeratin14 (C), and the endothelial-associated CD31 (D). Approximately 30% of cells were positive for α-smooth muscle actin (E). Cav-1 immunostaining in normal fibroblasts is shown in F and is membranous.

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