No conflicts of interest were declared.
Deciphering the epigenetic network in colorectal cancer†
Article first published online: 17 DEC 2012
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 229, Issue 1, pages 1–3, January 2013
How to Cite
Domínguez, G. (2013), Deciphering the epigenetic network in colorectal cancer. J. Pathol., 229: 1–3. doi: 10.1002/path.4094
Invited commentary for Wang et al. SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer. J Pathol 2013; 229: 12–24.
- Issue published online: 17 DEC 2012
- Article first published online: 17 DEC 2012
- Accepted manuscript online: 6 SEP 2012 06:01AM EST
- Manuscript Accepted: 18 AUG 2012
- Manuscript Received: 14 AUG 2012
- Manuscript Revised: 14 AUG 2012
- Colorectal cancer;
The sequential accumulation of genetic alterations has been classically considered responsible for the origin and subsequent progression of colorectal cancer, although recent cumulative data provide strong evidence of the significance of epigenetic changes in the development of this multi-step malignancy. Among the epigenetic alterations, miRNAs deregulation has emerged as an exciting and promising field in cancer research. In a recent issue of the Journal of Pathology, Wang and colleagues identify miR-149 as being silenced by methylation in colorectal cancer. The authors also identified Sp1 as a target of miR-149. These intriguing observations have important biological prognostic and therapeutic implications.