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Deciphering the epigenetic network in colorectal cancer

Authors

  • Gemma Domínguez

    Corresponding author
    • Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
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  • No conflicts of interest were declared.

  • Invited commentary for Wang et al. SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer. J Pathol 2013; 229: 12–24.

Correspondence to: G Domínguez, Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Spain. e-mail: gemma.dominguez@uam.es

Abstract

The sequential accumulation of genetic alterations has been classically considered responsible for the origin and subsequent progression of colorectal cancer, although recent cumulative data provide strong evidence of the significance of epigenetic changes in the development of this multi-step malignancy. Among the epigenetic alterations, miRNAs deregulation has emerged as an exciting and promising field in cancer research. In a recent issue of the Journal of Pathology, Wang and colleagues identify miR-149 as being silenced by methylation in colorectal cancer. The authors also identified Sp1 as a target of miR-149. These intriguing observations have important biological prognostic and therapeutic implications.

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