These authors shared last co-authorship.
The protein tyrosine phosphatase receptor type J is regulated by the pVHL–HIF axis in clear cell renal cell carcinoma
Version of Record online: 21 JAN 2013
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 229, Issue 4, pages 525–534, March 2013
How to Cite
Casagrande, S., Ruf, M., Rechsteiner, M., Morra, L., Brun-Schmid, S., von Teichman, A., Krek, W., Schraml, P. and Moch, H. (2013), The protein tyrosine phosphatase receptor type J is regulated by the pVHL–HIF axis in clear cell renal cell carcinoma. J. Pathol., 229: 525–534. doi: 10.1002/path.4107
No conflicts of interest were declared.
- Issue online: 15 FEB 2013
- Version of Record online: 21 JAN 2013
- Accepted manuscript online: 24 SEP 2012 09:13AM EST
- Manuscript Accepted: 12 SEP 2012
- Manuscript Revised: 20 AUG 2012
- Manuscript Received: 20 JUN 2012
|path4107-sup-0001-FigureS1.pdf||PDF document||134K||Figure S1. (A) Western blot showing HIF-2α down-regulation in 786-O cells with three different siHIF-2α (siHIF-2α #1, siHIF-2α #2, siHIF-2α #3) to exclude off target effects for changed PTPRJ expression. (B) Increased PTPRJ mRNA levels in 786-O cells and (C) in RCC4 cells after silencing of HIF-2α with siHIF-2α #2.|
|path4107-sup-0002-FigureS2.pdf||PDF document||59K||Figure S2. Kaplan–Meier plot of the overall survival of ccRCC patients with organ-confined (stage pT1/pT2) and locally advanced tumours (pT3/pT4).|
|path4107-sup-0003-FigureS3.pdf||PDF document||86K||Figure S3. (A) Western blot showing PTPRJ down-regulation in HK2 cells 72 h after transfection. (B) Proliferation of HK2 cells 24, 48, 72, and 96 h after transfection of siPTPRJ and siScrambled (control).|
|path4107-sup-0004-TableS1.pdf||PDF document||43K||Table S1. Clinico-pathological features and VHL mutation status of 17 ccRCC samples analysed for PTPRJ mRNA expression by qRT-PCR.|
|path4107-sup-0005-TableS2.pdf||PDF document||66K||Table S2. siRNA sequences.|
|path4107-sup-0006-TableS3.pdf||application/unknown||61K||Table S3. Location of the five HREs and three reverse HREs in the putative PTPRJ promoter.|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.