The role of promoter hypermethylation in fibroblast activation and fibrogenesis

Authors

  • Elisabeth M Zeisberg,

    1. Department of Cardiology and Pneumology, Göttingen University Medical Centre, Georg August University, Göttingen, Germany
    2. German Centre for Cardiovascular Research (DZHK), Göttingen, Germany
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  • Michael Zeisberg

    Corresponding author
    1. Department of Nephrology and Rheumatology, Göttingen University Medical Centre, Georg August University, Göttingen, Germany
    • Correspondence to: M Zeisberg, Department of Nephrology and Rheumatology, Göttingen University Medical Centre, Georg August University, Robert Koch Strasse 40, 37075 Göttingen, Germany. E-mail: mzeisberg@med.uni-goettingen.de

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  • No conflicts of interest were declared.

Abstract

The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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