Conflict of interest statement: OS has options in the company Olink Biosciences that commercializes the PLA technology.
P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model
Article first published online: 24 JAN 2013
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 229, Issue 5, pages 705–718, April 2013
How to Cite
Ribeiro, A. S., Sousa, B., Carreto, L., Mendes, N., Nobre, A. R., Ricardo, S., Albergaria, A., Cameselle-Teijeiro, J. F., Gerhard, R., Söderberg, O., Seruca, R., Santos, M. A., Schmitt, F. and Paredes, J. (2013), P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model. J. Pathol., 229: 705–718. doi: 10.1002/path.4143
- Issue published online: 13 MAR 2013
- Article first published online: 24 JAN 2013
- Accepted manuscript online: 26 NOV 2012 04:13AM EST
- Manuscript Accepted: 8 NOV 2012
- Manuscript Revised: 17 OCT 2012
- Manuscript Received: 24 APR 2012
|path4143-sup-0001-Appendix S1.doc||Word document||19162K||Appendix S1. Supplementary materials and methods|
|path4143-sup-0002-Table S1.doc||Word document||72K||Table S1. Summary of the results obtained in different studies that assessed the invasion role of P-cadherin in several cell lines, taking into account the pattern of expression of classical cadherins (namely E- and N-cadherin).|
|path4143-sup-0003-Table S2.doc||Word document||225K||Table S2. Summary of the clinical, pathological, and immunohistochemical features of the studied series of 467 invasive breast carcinomas, including E- and P-cadherin expression.|
|path4143-sup-0004-Figure S1.doc||Word document||220K||Figure S1. Functional evaluation of E- and P-cadherin expression in SUM149 breast cancer cell line.|
|path4143-sup-0005-Figure S2.doc||Word document||17520K||Figure S2. Quantification of specific protein–protein interactions in breast cancer cells after E- and P-cadherin transcription silencing by specific siRNAs in SUM149.|
|path4143-sup-0006-Figure S3.doc||Word document||466K||Figure S3. BrdU proliferation assay.|
|path4143-sup-0007-Figure S4.doc||Word document||362K||Figure S4. Validation of microarray data of selected genes by qRT-PCR in SUM149 breast cancer cells.|
|path4143-sup-0008-Figure S5.doc||Word document||391K||Figure S5. Activity of Rac and Rho in BT20 breast cancer cells.|
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