Current address: Department of Pediatrics, Division of Hematology–Oncology, Baylor College of Medicine, Houston, Texas, USA.
Inhibition of the LKB1–AMPK pathway by the Epstein–Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells
Article first published online: 7 JUN 2013
Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Journal of Pathology
Volume 230, Issue 3, pages 336–346, July 2013
How to Cite
Lo, A. K.-F., Lo, K.-W., Ko, C.-W., Young, L. S. and Dawson, C. W. (2013), Inhibition of the LKB1–AMPK pathway by the Epstein–Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells. J. Pathol., 230: 336–346. doi: 10.1002/path.4201
No conflicts of interest were declared.
- Issue published online: 7 JUN 2013
- Article first published online: 7 JUN 2013
- Accepted manuscript online: 17 APR 2013 06:05AM EST
- Manuscript Accepted: 8 APR 2013
- Manuscript Revised: 29 MAR 2013
- Manuscript Received: 10 DEC 2012
|path4201-sup-0001-Appendix S1.docx||Word 2007 document||18K||Appendix S1. Supplementary Materials and Methods|
|path4201-sup-0002-Figure s1.tif||TIFF image||1943K||AICAR treatment of LMP1-expressing NP69 cells. NP69-pLNSX and NP69-LMP1 cells were treated with increasing doses of AICAR for 2 hrs prior to harvesting and immunoblotting for the indicated proteins. Relative protein levels were calculated using drug free pLNSX vector control as a reference (set at 1). The ratios of pLKB1/LKB1 and pAMPKα/AMPKα were calculated and are shown in the form of bar charts.|
|path4201-sup-0003-Figure s2.tif||TIFF image||1834K||AICAR treatment of LMP1-expressing C666-1 NPC cells. C666-1 cells were treated with various doses of AICAR and/or 5-FU for 2 hrs prior to harvesting and immunoblotting for the indicated proteins. Relative protein levels were calculated using drug free C666-1 cells as a reference (set at 1). The ratio of pAMPKα/AMPKα was calculated and shown as a bar chart.|
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