Research Article

Antioxidant status decreases in children with acute lymphoblastic leukemia during the first six months of chemotherapy treatment†

  1. Deborah D. Kennedy PhD1,
  2. Elena J. Ladas MS, RD1,
  3. Susan R. Rheingold MD3,
  4. Jeffrey Blumberg PhD2,
  5. Kara M. Kelly MD1,*

Article first published online: 27 DEC 2004

DOI: 10.1002/pbc.20307

Issue

Pediatric Blood & Cancer

Pediatric Blood & Cancer

Volume 44, Issue 4, pages 378–385, April 2005

Additional Information

How to Cite

Kennedy, D. D., Ladas, E. J., Rheingold, S. R., Blumberg, J. and Kelly, K. M. (2005), Antioxidant status decreases in children with acute lymphoblastic leukemia during the first six months of chemotherapy treatment. Pediatric Blood & Cancer, 44: 378–385. doi: 10.1002/pbc.20307

Author Information

  1. 1

    Division of Pediatric Oncology, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, New York

  2. 2

    USDA Jean Mayer Human Nutrition Research Center for Aging at Tufts University, Boston, Massachusetts

  3. 3

    Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

*Division of Pediatric Oncology, Columbia University, 161 Fort Washington Ave., Irving Pavilion 7, New York, NY 10032.

  1. †

    The study was performed at the Division of Pediatric Oncology, Department of Pediatrics, College of Physicians & Surgeons of Columbia University.

Publication History

  1. Issue published online: 14 FEB 2005
  2. Article first published online: 27 DEC 2004
  3. Manuscript Accepted: 10 NOV 2004
  4. Manuscript Received: 11 MAR 2004

Funded by

  • American Institute for Cancer Research. Grant Number: 98B072
  • American Cancer Society Herbert Irving Comprehensive Cancer Center. Grant Number: 7-88625
  • Lerner and Schwartz Family

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Keywords:

  • ALL;
  • antioxidant;
  • children;
  • 8-oxo-dG;
  • side effects

Abstract

Background

Children undergoing treatment for acute lymphoblastic leukemia (ALL) receive combination chemotherapy and many of the components are associated with free radical production.

Procedure

Among 103 children newly diagnosed with ALL, plasma concentrations of antioxidants, total antioxidant capacity (ORAC), and DNA oxidized base 8-oxodeoxyguanosine (8-oxo-dG) were analyzed at baseline and 3 and 6 months after diagnosis.

Results

Plasma vitamin A, antioxidants, 8-oxo-dG, and ORAC changed from diagnosis through the first 6 months of ALL therapy. In patients with higher plasma concentrations of vitamin A, E, total carotenoids, ORAC, and 8-oxo-dG there was a beneficial association with fewer dose reductions, fewer infections, improved quality of life, less delay in chemotherapy treatment schedule, reduced toxicity, and fewer days spent in the hospital. There were also adverse relationships demonstrated.

Conclusions

Among children with ALL, antioxidant levels and oxidative stress appear to be associated with duration and complications of treatment. © 2004 Wiley-Liss, Inc.

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