Chemotherapy and attentional dysfunction in survivors of childhood acute lymphoblastic leukemia: Effect of treatment intensity
Article first published online: 3 APR 2005
Copyright © 2005 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 45, Issue 3, pages 281–290, September 2005
How to Cite
Buizer, A. I., de Sonneville, L. M.J., van den Heuvel–Eibrink, M. M. and Veerman, A. J.P. (2005), Chemotherapy and attentional dysfunction in survivors of childhood acute lymphoblastic leukemia: Effect of treatment intensity. Pediatr. Blood Cancer, 45: 281–290. doi: 10.1002/pbc.20397
- Issue published online: 13 JUL 2005
- Article first published online: 3 APR 2005
- Manuscript Accepted: 1 FEB 2005
- Manuscript Received: 21 JUL 2004
- Dutch Cancer Society. Grant Number: AZVU 2001–2390
- VU Childhood Cancer Research Fund (VONK)
- late effects;
- Wilms tumor
Central nervous system (CNS) directed chemotherapy is replacing prophylactic cranial irradiation in treatment protocols for childhood acute lymphoblastic leukemia (ALL), mainly to reduce long-term neuropsychological sequelae. We evaluated the effects of chemotherapy on attentional function in survivors of ALL and examined whether possible deficits are related to treatment intensity.
In a multi-center study, we compared attentional function in 36 children at least 1 year after finishing treatment with chemotherapy only for ALL, with a cancer control group consisting of 39 Wilms tumor patients and with 110 healthy children. We differentiated between standard- and intensified ALL treatment. The role of previously reported risk factors for neuropsychological deficits was also assessed.
After chemotherapy, attentional deficits were detected in patients with ALL, but not in Wilms tumor patients. Children treated according to standard ALL protocols performed worse than healthy controls on only 1 of 10 outcome measures (P = 0.004), while those who had received intensified treatment performed worse on four outcome measures (0.0001 < P < 0.004). Higher treatment intensity, young age at diagnosis, and female gender were associated with worse performance.
CNS-directed chemotherapy, even in the absence of cranial irradiation, is associated with attentional dysfunction in survivors of childhood ALL, particularly in case of intensified treatment protocols. These sequelae stress the importance of reducing doses of neurotoxic chemotherapy as much as possible in the design of future treatment protocols for ALL. © 2005 Wiley-Liss, Inc.