Ovarian germ cell tumors in children: A clinical study of 66 patients
Article first published online: 3 OCT 2005
Copyright © 2005 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 46, Issue 4, pages 459–464, April 2006
How to Cite
De Backer, A., Madern, G. C., Oosterhuis, J. W., Hakvoort-Cammel, F. G.A.J. and Hazebroek, F. W.J. (2006), Ovarian germ cell tumors in children: A clinical study of 66 patients. Pediatr. Blood Cancer, 46: 459–464. doi: 10.1002/pbc.20633
- Issue published online: 15 FEB 2006
- Article first published online: 3 OCT 2005
- Manuscript Accepted: 23 AUG 2005
- Manuscript Received: 21 JAN 2005
- germ cell tumor, ovary;
- teratoma, ovary;
- yolk sac tumor, dysgerminoma
Ovarian germ cell tumors are rare in childhood. The aim of this study is to review clinical presentation, management, and outcome in a two-center series of girls with ovarian germ cell tumor.
The records of 66 patients (median age 9 years) with histologically proven ovarian germ cell tumor (either benign or malignant), treated over a 44-year-span, were reviewed.
Pain and an abdominal mass were the most frequent symptoms. The tumors were right-sided in 35, left-sided in 28, and bilateral in 3. Most patients (52) were stage I, 4 were stage II, 6 stage III, and 1, with liver metastases, stage IV. Sixteen patients had an emergency operation for tumor torsion. Unilateral salpingo-oophorectomy was the most frequently performed procedure (n = 46), and ovarian-sparing tumorectomy was performed in 9 patients (one bilaterally). Histologically, teratomas were found most frequently (mature: 45, immature: 9), followed by mixed tumors (n = 7), yolk sac tumors (n = 3), dysgerminoma (n = 2), gonadoblastoma (n = 2), and embryonal carcinoma (n = 1). Surgical removal of the tumor with or without the ovary and/or adnex was the sole treatment in 55 patients, chemotherapy was administered in 10 and radiotherapy + chemotherapy in one. Intra-operative spillage of tumoral fluid occurred in six; this did not influence outcome in five. Recurrence was observed in three patients. Two patients, with malignant disease, died. The 64 survivors are now between 8 months and 44 years after treatment.
With a recurrence rate of 4.5% and a mortality rate of 3%, this series confirms the excellent prognosis for girls with ovarian germ cell tumor (GCT). Pediatr Blood Cancer 2006, 46:459–464. © 2005 Wiley-Liss, Inc.