Overt testicular disease (OTD) at diagnosis is not associated with a poor prognosis in childhood acute lymphoblastic leukemia: Results of the EORTC CLG study 58881
Article first published online: 15 DEC 2005
Copyright © 2005 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 49, Issue 3, pages 344–348, September 2007
How to Cite
Sirvent, N., Suciu, S., Bertrand, Y., Uyttebroeck, A., Lescoeur, B. and Otten, J. (2007), Overt testicular disease (OTD) at diagnosis is not associated with a poor prognosis in childhood acute lymphoblastic leukemia: Results of the EORTC CLG study 58881. Pediatr. Blood Cancer, 49: 344–348. doi: 10.1002/pbc.20716
- Issue published online: 13 JUL 2007
- Article first published online: 15 DEC 2005
- Manuscript Accepted: 27 OCT 2005
- Manuscript Received: 16 JUL 2005
- National Cancer Institute. Grant Numbers: 5U10 CA11488-18S2, 5U10 CA11488-35
- acute lymphoblastic leukemia;
- prognostic factor;
- testicular involvement
To assess the prognosis of overt testicular disease (OTD) at diagnosis of acute lymphoblastic leukemia (ALL), we analyzed the outcome of 1,165 boys enrolled in EORTC trial 58881. Thirteen (1.1%) boys had OTD associated with bad prognostic features. Patients with and without OTD did not differ in event-free survival (EFS) (P = 0.30) or overall survival (OS) (P = 0.54), even after adjustment for the three most important independent factors (NCI risk group, presence of very high risk features, type of asparaginase used). OTD was not an independent prognostic factor. These results may be due to the use of risk-adjusted intensive chemotherapy comprising high-dose methotrexate. Pediatr Blood Cancer 2007;49:344–348. © 2005 Wiley-Liss, Inc.