Intensive extracorporeal photochemotherapy in pediatric patients with chronic graft-versus-host disease (cGVHD)

Authors

  • Oznur Duzovali MD,

    Corresponding author
    1. Department of Pediatrics, Division of Pediatric Oncology, Mersin University, Zeytinlibahce, Mersin, Turkey
    • Department of Pediatrics, Division of Pediatric Oncology, Mersin University, 33079 Zeytinlibahce, Mersin, Turkey.
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  • Ka Wah Chan MD

    1. Pediatric Blood and Marrow Transplantation, Texas Transplant Institute, Ewing Halsell, San Antonio, Texas
    2. Department of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas
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Abstract

Extracorporeal photochemotherapy (ECP) is an alternative treatment approach in the management of chronic graft-versus-host disease (cGVHD). However, few reports have investigated the optimal treatment schedule of ECP. We treated seven pediatric patients with steroid-resistant or -dependent cGVHD with ECP. Using the Therakos UVAR XTS system, ECP was begun three (three patients) or five (four patients) times a week initially. Complete and partial responses were obtained in three patients. Three of seven patients died of GVHD-related complications. In this group initial intensive ECP did not improve the rate of response. However, this schedule appeared well tolerated. Pediatr Blood Cancer 2007;48:218–221. © 2006 Wiley-Liss, Inc.

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