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Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors

  1. Dev R. Puri MD1,
  2. Paul A. Meyers MD2,
  3. Dennis H. Kraus MD3,
  4. Michael P. LaQuaglia MD3,
  5. Leonard H. Wexler MD2,
  6. Suzanne L. Wolden MD1,*

Article first published online: 19 JUL 2006

DOI: 10.1002/pbc.20947

Issue

Pediatric Blood & Cancer

Pediatric Blood & Cancer

Volume 50, Issue 1, pages 167–169, January 2008

Additional Information

How to Cite

Puri, D. R., Meyers, P. A., Kraus, D. H., LaQuaglia, M. P., Wexler, L. H. and Wolden, S. L. (2008), Radiotherapy in the multimodal treatment of extrarenal extracranial malignant rhabdoid tumors. Pediatr. Blood Cancer, 50: 167–169. doi: 10.1002/pbc.20947

Author Information

  1. 1

    Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York

  2. 2

    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York

  3. 3

    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York

*Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021.

Publication History

  1. Issue published online: 19 NOV 2007
  2. Article first published online: 19 JUL 2006
  3. Manuscript Accepted: 30 MAY 2006
  4. Manuscript Received: 21 FEB 2006

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Keywords:

  • chemotherapy;
  • extracranial;
  • extrarenal;
  • malignant rhabdoid tumor;
  • radiotherapy;
  • surgery

Abstract

Extrarenal extracranial malignant rhabdoid tumors (MRT) are extremely rare and typically lethal. No consensus exists on an optimal treatment approach, and, in particular, the role of radiation therapy (RT) is poorly defined. We report on three children who underwent multimodality treatment including surgery, chemotherapy (CMT), and RT. Two of these patients are alive and without evidence of disease 6½ and 7 years after diagnosis and one has expired. Our limited experience suggests that RT in the setting of CMT and surgery has the potential to prolong survival with acceptable toxicity, but outcomes are inconsistent and further study is necessary. Pediatr Blood Cancer 2008;50:167–169. © 2006 Wiley-Liss, Inc.

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