Gene expression profile of idiopathic thrombocytopenic purpura (ITP)
Article first published online: 24 AUG 2006
Copyright © 2006 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Special Issue: 2nd Intercontinental Childhood ITP Study Group (ICIS) Expert Meeting on “Critical Issues and Future Research of ITP”, September 16–18, 2006, Yverdon, Switzerland
Volume 47, Issue S5, pages 675–677, 15 October 2006
How to Cite
Sood, R., Wong, W., Jeng, M. and Zehnder, J. L. (2006), Gene expression profile of idiopathic thrombocytopenic purpura (ITP). Pediatr. Blood Cancer, 47: 675–677. doi: 10.1002/pbc.20981
- Issue published online: 24 AUG 2006
- Article first published online: 24 AUG 2006
- Manuscript Received: 20 JUN 2006
- Manuscript Accepted: 20 JUN 2006
- Stanford Outreach Funds
To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon-regulated genes and TLR7, as well many less-well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP. Pediatr Blood Cancer 2006;47:675–677. © 2006 Wiley-Liss, Inc.