Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: A critical appraisal from literature analysis
Article first published online: 24 AUG 2006
Copyright © 2006 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Special Issue: 2nd Intercontinental Childhood ITP Study Group (ICIS) Expert Meeting on “Critical Issues and Future Research of ITP”, September 16–18, 2006, Yverdon, Switzerland
Volume 47, Issue S5, pages 653–656, 15 October 2006
How to Cite
Ruggeri, M., Fortuna, S. and Rodeghiero, F. (2006), Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: A critical appraisal from literature analysis. Pediatr. Blood Cancer, 47: 653–656. doi: 10.1002/pbc.20983
- Issue published online: 24 AUG 2006
- Article first published online: 24 AUG 2006
- Manuscript Received: 21 JUN 2006
- Manuscript Accepted: 21 JUN 2006
We have carried out a literature review on diagnosis and treatment of idiopathic thrombocytopenic purpura (ITP) in adults, based on the articles published during the years 2000–2005, aimed at assessing the variability in the terminology and clinical definitions. A total of 85 articles were considered eligible. In particular, the platelet level for initiating treatment, the definition of response to treatment in terms of platelet count and timing, the evaluation of bleeding symptoms, the criteria to define chronic and refractory forms were compared in the different articles. The study revealed confounding terminology and an unacceptable heterogeneity for clinical definitions relevant to management decisions and outcomes reporting. Pediatr Blood Cancer 2006;47:653–656. © 2006 Wiley-Liss, Inc.