Gene polymorphisms and behavior
Article first published online: 20 FEB 2007
Copyright © 2007 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 48, Issue 7, pages 736–737, 15 June 2007
How to Cite
McGuffin, P. (2007), Gene polymorphisms and behavior. Pediatr. Blood Cancer, 48: 736–737. doi: 10.1002/pbc.21111
- Issue published online: 19 APR 2007
- Article first published online: 20 FEB 2007
- Manuscript Received: 31 OCT 2006
- Manuscript Accepted: 31 OCT 2006
- bipolar disorder;
- single gene disorder;
- single nucleotide polymorphisms
Genetics has a entered golden post genomic era that promises to greatly improve our understanding of the etiology of complex familial disorders. Many forms of behavior are familial but Mendelian disorders are rare, and common conditions have complex inheritance. Twin and adoption studies confirm that major psychiatric disorders such as schizophrenia and bipolar affective disorder are highly heritable. There is also emerging evidence of some overlap between these disorders. Several susceptibility loci for schizophrenia have been identified, at least one of which is also a susceptibility gene for bipolar disorder. The first susceptibility genes involved in major psychiatric disorders have been identified and more will soon follow with the exploitation of emerging technologies that allow whole genome association studies. Pediatr Blood Cancer 2007;48:736–737. © 2007 Wiley-Liss, Inc.