The data presented in this publication has previously been presented in poster and abstract form at American Society of Clinical Oncology meeting (abstract 8520) 2005.
A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group study†
Article first published online: 29 JAN 2007
Copyright © 2007 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 50, Issue 2, pages 254–258, February 2008
How to Cite
Bond, M., Bernstein, M. L., Pappo, A., Schultz, K. R., Krailo, M., Blaney, S. M. and Adamson, P. C. (2008), A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: A Children's Oncology Group study. Pediatr. Blood Cancer, 50: 254–258. doi: 10.1002/pbc.21132
- Issue published online: 4 DEC 2007
- Article first published online: 29 JAN 2007
- Manuscript Accepted: 14 NOV 2006
- Manuscript Received: 22 SEP 2006
- COG grant. Grant Number: U10 CA 98543
- desmoplastic small round cell;
Imatinib mesylate is a small molecule inhibitor of certain tyrosine kinases, most notably the chimeric bcr-abl fusion protein found in CML. It also inhibits KIT and PDGF receptor tyrosine kinases in vitro. Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, and synovial sarcomas often overexpress KIT or the PDGF receptor. A phase II study of imatinib in children and young adults with select solid tumors was performed.
Patients less than 30 years of age with refractory or recurrent Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, synovial sarcomas or GIST were eligible. Imatinib was administered daily for 28 day courses at a dose of 440 mg/m2/day. Responses were assessed according to Response Evaluation Criteria in Solid Tumor (RECIST).
Seventy eligible patients, 48 male and 22 female, were enrolled and 59 were evaluable for response. Only one partial response was seen among 24 patients with Ewing sarcoma. There were no other objective responses. Hemorrhagic pleural effusions occurred in seven patients with pulmonary lesions, four of whom had progressive disease at the time of the hemorrhage. Intratumoral bleeding was reported in three additional patients.
Imatinib as a single agent at a dose of 440 mg/m2/day demonstrated little or no activity as a single agent in children with relapsed or refractory Ewing sarcoma, osteosarcoma, neuroblastoma, or desmoplastic small round cell tumors. Pediatr Blood Cancer 2008;50:254–258. © 2007 Wiley-Liss, Inc.