Review Article

Osteonecrosis in children and adolescents with cancer

  1. Ronald D. Barr MB ChB, MD1,*,
  2. Alessandra Sala MD, PhD1,2

Article first published online: 6 DEC 2007

DOI: 10.1002/pbc.21405

Issue

Pediatric Blood & Cancer

Pediatric Blood & Cancer

Special Issue: Nutrition and Cancer in Children The Second International Workshop, Puebla, Mexico, November 1–5, 2006

Supplement: Puebla Workshop Supplement

Volume 50, Issue Supplement 2, pages 483–485, February 2008

Additional Information

How to Cite

Barr, R. D. and Sala, A. (2008), Osteonecrosis in children and adolescents with cancer. Pediatric Blood & Cancer, 50: 483–485. doi: 10.1002/pbc.21405

Author Information

  1. 1

    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada

  2. 2

    Department of Pediatrics, University of Milano-Bicocca, Monza, Milan, Italy

*Department of Pediatrics, McMaster University, HSC 3N27, 1200 Main Street West, Hamilton, Ontario, Canada L8S 4J9.

Publication History

  1. Issue published online: 6 DEC 2007
  2. Article first published online: 6 DEC 2007
  3. Manuscript Received: 17 SEP 2007
  4. Manuscript Accepted: 17 SEP 2007

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Keywords:

  • adolescent;
  • child;
  • neoplasms;
  • osteonecrosis

Abstract

Osteonecrosis is recognized increasingly as a complication of the treatment of cancer in young people, especially those with acute lymphoblastic leukemia and non-Hodgkin lymphoma, reflecting a probable pathogenetic role of steroid therapy. Children ≥10 years of age and Whites are at particular risk, and genetic predispositions have been identified. The disorder affects weight-bearing joints predominantly. It is commonly bilateral and multi-articular. Treatment options include both surgical and non-surgical interventions. Pediatr Blood Cancer 2008;50:483–485. © 2007 Wiley-Liss, Inc.

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