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Osteonecrosis in children and adolescents with cancer

Authors

  • Ronald D. Barr MB ChB, MD,

    Corresponding author
    1. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    • Department of Pediatrics, McMaster University, HSC 3N27, 1200 Main Street West, Hamilton, Ontario, Canada L8S 4J9.
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  • Alessandra Sala MD, PhD

    1. Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    2. Department of Pediatrics, University of Milano-Bicocca, Monza, Milan, Italy
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Abstract

Osteonecrosis is recognized increasingly as a complication of the treatment of cancer in young people, especially those with acute lymphoblastic leukemia and non-Hodgkin lymphoma, reflecting a probable pathogenetic role of steroid therapy. Children ≥10 years of age and Whites are at particular risk, and genetic predispositions have been identified. The disorder affects weight-bearing joints predominantly. It is commonly bilateral and multi-articular. Treatment options include both surgical and non-surgical interventions. Pediatr Blood Cancer 2008;50:483–485. © 2007 Wiley-Liss, Inc.

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