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Review Article
Osteoporosis in children with cancer
Article first published online: 6 DEC 2007
DOI: 10.1002/pbc.21407
Copyright © 2007 Wiley-Liss, Inc.
Issue
1545-5017/asset/cover.gif?v=1&s=a75210663ec4a312a5bd8e3022f1967dde569328 "Pediatric Blood & Cancer")
Pediatric Blood & Cancer
Special Issue: Nutrition and Cancer in Children The Second International Workshop, Puebla, Mexico, November 1–5, 2006
Supplement: Puebla Workshop Supplement
Volume 50, Issue Supplement 2, pages 474–478, February 2008
Additional Information
How to Cite
van der Sluis, I. M. and van den Heuvel-Eibrink, M. M. (2008), Osteoporosis in children with cancer. Pediatric Blood & Cancer, 50: 474–478. doi: 10.1002/pbc.21407
Publication History
- Issue published online: 6 DEC 2007
- Article first published online: 6 DEC 2007
- Manuscript Received: 17 SEP 2007
- Manuscript Accepted: 17 SEP 2007
- Abstract
- Article
- References
- Cited By
Keywords:
- bone mineral density;
- childhood cancer;
- fractures;
- osteoporosis;
- risk factors;
- treatment
Abstract
As increasing numbers of childhood cancer patients are surviving, the long-term complications of the disease and its treatment have become ever more increasingly important. Reduced bone mineral density and increased fracture risk have been reported during and after treatment of children with cancer. The causes of osteoporosis are multifactorial. Among others, the disease itself, chemotherapy, irradiation and genetic susceptibility play a role. Bone mineral density in later life depends largely on the peak bone mass achieved in adolescence or young adulthood. Therefore, optimizing peak bone mass is of clinical importance. Preventive and therapeutic strategies, such as calcium and vitamin D supplementation, physical activity and bisphosphonates, are considered. Pediatr Blood Cancer 2008;50:474–478. © 2007 Wiley-Liss, Inc.