Disclosure: The authors have no relevant conflicts of interest to disclose.
Influenza-associated morbidity in children with cancer†
Article first published online: 31 JAN 2008
Copyright © 2008 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 50, Issue 5, pages 983–987, May 2008
How to Cite
Tasian, S. K., Park, J. R., Martin, E. T. and Englund, J. A. (2008), Influenza-associated morbidity in children with cancer. Pediatr. Blood Cancer, 50: 983–987. doi: 10.1002/pbc.21472
- Issue published online: 21 MAR 2008
- Article first published online: 31 JAN 2008
- Manuscript Accepted: 14 NOV 2007
- Manuscript Received: 28 FEB 2007
- respiratory virus
The clinical impact of influenza in children undergoing therapy for cancer is not well-described in the literature.
Laboratory-documented influenza infection in pediatric oncology patients cared for in a single regional pediatric medical center between July 2000 and June 2005 was identified by review of medical and laboratory records.
Twenty-seven clinical encounters were identified in 24 pediatric oncology patients with influenza infection. Eighty-three percent of patients were receiving chemotherapy for hematologic or solid malignancies. Two-thirds of patients were hospitalized for a median duration of 7.4 days; 40% of patients experienced a delay in scheduled chemotherapy as result of influenza infection. Most children (67%) were not neutropenic, although 63% were lymphopenic. Importantly, 15% of children with influenza had simultaneously diagnosed bacteremia. Concomitant pathogens included Pseudomonas aeruginosa, Enterobacter cloacae, Enterococcus faecalis, and coagulase-negative Staphylococcus. Primary influenza pneumonia and/or respiratory failure occurred in three children, and ventilatory support was required in four clinical encounters. Antiviral medications were administered to 63% of patients within 2 days of influenza diagnosis.
Pediatric oncology patients experienced significant influenza-associated morbidities. Influenza infection should be considered in febrile children with respiratory symptoms during the respiratory viral season, as well as concurrent bacterial or fungal infections. Pediatr Blood Cancer 2008;50:983–987. © 2008 Wiley-Liss, Inc.