The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy-related weight loss in children
Version of Record online: 17 DEC 2008
Copyright © 2008 Wiley-Liss, Inc.
Pediatric Blood & Cancer
Volume 52, Issue 5, pages 571–574, May 2009
How to Cite
Bayram, I., Erbey, F., Celik, N., Nelson, J. L. and Tanyeli, A. (2009), The use of a protein and energy dense eicosapentaenoic acid containing supplement for malignancy-related weight loss in children. Pediatr. Blood Cancer, 52: 571–574. doi: 10.1002/pbc.21852
- Issue online: 16 MAR 2009
- Version of Record online: 17 DEC 2008
- Manuscript Accepted: 8 OCT 2008
- Manuscript Received: 29 JAN 2008
- eicosapentaenoic acid;
- n-3 fatty acids
The aim of nutritional therapy in cancer patients is to prevent weight loss and to improve functional capacity and quality of life. Clinical studies however, have continued to demonstrate that a reduction in body weight loss is difficult to achieve in cancer cachexia. Several studies have shown that supplementation with eicosapentaenoic acid (EPA), an omega-3 fatty acid, has anti-cachectic effects in adult cancer patients. This study evaluated the clinical effects of a protein and energy dense EPA containing nutritional supplement in a group of pediatric cancer patients receiving active chemotherapy treatment.
The study was a prospective, randomized, single center, open-label design. Fifty-two patients diagnosed with pediatric malignant disease and receiving intensive chemotherapy were included. Thirty-three patients received a nutritional supplement containing EPA in addition to their regular food intake. Nineteen control patients did not receive supplementation. Patients were examined and their data (body weight, body mass index, and weight percentile) were recorded regularly once a month for 3 months. A subgroup of patients was evaluated for 6 months.
At 3 months, there were significantly fewer patients in the treatment group as compared to controls that showed losses in body weight (P = 0.001), BMI (P = 0.002), and a negative deviation in weight percentile (P = 0.021). In addition, remission rate was significantly (P = 0.036) higher in the treatment group as compared to controls.
This study demonstrates a decrease in cancer-induced weight loss in pediatric patients fed a protein and energy dense nutrition supplement containing EPA. Pediatr Blood Cancer 2009;52:571–574. © 2008 Wiley-Liss, Inc.