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Review
Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature
Article first published online: 5 DEC 2008
DOI: 10.1002/pbc.21869
Copyright © 2008 Wiley-Liss, Inc.
Additional Information
How to Cite
Buizer, A. I., de Sonneville, L. M. and Veerman, A. J. (2009), Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature. Pediatric Blood & Cancer, 52: 447–454. doi: 10.1002/pbc.21869
Publication History
- Issue published online: 9 FEB 2009
- Article first published online: 5 DEC 2008
- Manuscript Accepted: 20 OCT 2008
- Manuscript Received: 25 APR 2008
Funded by
- Dutch Cancer Society. Grant Number: AZVU 2001—2390
- VU Childhood Cancer Research Fund (VONK)
- Abstract
- Article
- References
- Cited By
Keywords:
- ALL;
- chemotherapy;
- cognition;
- late effects;
- neurotoxicity
Abstract
Chemotherapy-only treatment has increasingly become the standard of treatment for childhood acute lymphoblastic leukemia (ALL). The objective of this review is to assess the present state of knowledge of the neurocognitive effects of central nervous system (CNS)-directed chemotherapy in children with ALL, and to formulate directions for future research. We performed a review of studies published since 1997, that included an ALL group treated with chemotherapy only and a control group. Twenty-one studies met our inclusion criteria. There is evidence of subtle long-term neurocognitive deficits survivors of childhood ALL after treatment with chemotherapy only. These involve mainly processes of attention and of executive functioning, while global intellectual function is relatively preserved. Young age at diagnosis and female sex emerged as risk factors. Pediatr Blood Cancer 2009;52:447–454. © 2008 Wiley-Liss, Inc.