Research Article

Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma†

  1. Eri Taniguchi PhD1,
  2. Min Jung Cho MD1,
  3. Benjamin R. Arenkiel PhD2,
  4. Mark S. Hansen2,
  5. Omar J. Rivera PhD1,
  6. Amanda T. McCleish1,
  7. Stephen J. Qualman MD3,
  8. Denis C. Guttridge PhD4,
  9. Matthew P. Scott PhD5,
  10. Mario R. Capecchi PhD2,
  11. Charles Keller MD1,*

Article first published online: 11 FEB 2009

DOI: 10.1002/pbc.21968

Issue

Pediatric Blood & Cancer

Pediatric Blood & Cancer

Volume 53, Issue 2, pages 136–144, August 2009

Additional Information

How to Cite

Taniguchi, E., Cho, M. J., Arenkiel, B. R., Hansen, M. S., Rivera, O. J., McCleish, A. T., Qualman, S. J., Guttridge, D. C., Scott, M. P., Capecchi, M. R. and Keller, C. (2009), Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr. Blood Cancer, 53: 136–144. doi: 10.1002/pbc.21968

Author Information

  1. 1

    Departments of Cellular & Structural Biology and Pediatrics, Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas

  2. 2

    Howard Hughes Medical Institute and Department of Human Genetics, University of Utah, Salt Lake City, Utah

  3. 3

    Department of Laboratory Medicine, Columbus Children's Hospital, Children's Research Institute, Columbus, Ohio

  4. 4

    Human Cancer Genetics Program, The Ohio State University College of Medicine, Columbus, Ohio

  5. 5

    Howard Hughes Medical Institute and Departments of Developmental Biology, Genetics, and Bioengineering, Stanford University School of Medicine, Stanford, California

*Greehey Children's Cancer Research Institute, University of Texas Health Science Center, 8403 Floyd Curl Drive, MC-7784, San Antonio, TX 78229-3900.

  1. †

    The authors declare no conflicts of interest.

Publication History

  1. Issue published online: 9 JUN 2009
  2. Article first published online: 11 FEB 2009
  3. Manuscript Accepted: 13 JAN 2009
  4. Manuscript Received: 24 DEC 2008

Funded by

  • Pediatric Brain Tumor Foundation of the United States
  • St. Baldrick's Foundation
  • National Brain Tumor Society
  • Cancer Therapy and Research Center. Grant Number: P30CA54174
  • Huntsman Cancer Institute's Center for Children

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